Genetic models of dopamine dysfunction

Raul Gainetdinov (Italian Institute of Technology)
Host Institution: 
Lomonosov' Moscow State University

21.10.2010 auditorium 462 Bio-faculty 15.00
Genetic models of dopamine dysfunction
Raul R. Gainetdinov
Senior Researcher, Department of Neuroscience and Brain Technologies Italian Institute of Technology, Genova, Italy Adjunct Associate Professor, Department of Cell Biology, Duke University Durham, NC, USA
Catecholaminergic neurotransmitter dopamine involved in a variety of physiological functions ranging from voluntary movement and reward to hormonal regulation and hypertension. Pharmacological agents targeting dopaminergic neurotransmission have been clinically used in the management of several neuro-psychiatric disorders, including Parkinson’s disease, schizophrenia, bipolar disorder, Huntington’s disease, attention deficit hyperactivity disorder (ADHD) and Tourette syndrome. Five different dopamine receptor subtypes (D1-D5) have been cloned and characterized. Numerous advances have occurred in understanding the general structural, biochemical and functional properties of dopamine receptors that have led to the development of multiple pharmacologically active compounds that directly target dopamine receptors. Recent progress in understanding the complex biology of dopamine receptor-related signal transduction mechanisms in vivo has revealed that dopamine receptors can regulate myriads of cellular responses to fine-tune dopamine-related functions. To understand the role of aberrant dopaminergic transmission in the pathology of brain disorders several genetic mouse models have been developed.  Investigations performed in mice with genetically enhanced or reduced dopaminergic transmission will be discussed.